作者
Alexander C Ford, Eamonn MM Quigley, Brian E Lacy, Anthony J Lembo, Yuri A Saito, Lawrence R Schiller, Edy E Soffer, Brennan MR Spiegel, Paul Moayyedi
发表日期
2014/10/1
来源
Official journal of the American College of Gastroenterology| ACG
卷号
109
期号
10
页码范围
1547-1561
出版商
LWW
简介
OBJECTIVES:
Irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC) are functional bowel disorders. Evidence suggests that disturbance in the gastrointestinal microbiota may be implicated in both conditions. We performed a systematic review and meta-analysis to examine the efficacy of prebiotics, probiotics, and synbiotics in IBS and CIC.
METHODS:
MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (up to December 2013). Randomized controlled trials (RCTs) recruiting adults with IBS or CIC, which compared prebiotics, probiotics, or synbiotics with placebo or no therapy, were eligible. Dichotomous symptom data were pooled to obtain a relative risk (RR) of remaining symptomatic after therapy, with a 95% confidence interval (CI). Continuous data were pooled using a standardized or weighted mean difference with a 95% CI.
RESULTS:
The search strategy identified …
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AC Ford, EMM Quigley, BE Lacy, AJ Lembo, YA Saito… - Official journal of the American College of …, 2014