作者
Alexander Charles Ford, Nicholas J Talley, Philip S Schoenfeld, Eamonn MM Quigley, Paul Moayyedi
发表日期
2009/3/1
来源
Gut
卷号
58
期号
3
页码范围
367-378
出版商
BMJ Publishing Group
简介
Objective
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Evidence for treatment of the condition with antidepressants and psychological therapies is conflicting.
Design
Systematic review and meta-analysis of randomised controlled trials (RCTs). MEDLINE, EMBASE and the Cochrane Controlled Trials Register were searched (up to May 2008).
Setting
RCTs based in primary, secondary and tertiary care.
Patients
Adults with IBS.
Interventions
Antidepressants versus placebo, and psychological therapies versus control therapy or “usual management”.
Main outcome measures
Dichotomous symptom data were pooled to obtain a relative risk (RR) of remaining symptomatic after therapy, with a 95% confidence interval (CI). The number needed to treat (NNT) was …
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