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The aim of this chapter is to ‘translate’the research strategy of the Actor-Network Theory (ANT) in Management and Organization Studies (MOS), with reference to research on Academic Entrepreneurship. The concept of ‘amphibious scientist’, recalled in the title, was introduced in a research program on the emergence of markets and organizations from a sociological perspective. Padgett and Powell (2012) have investigated the development of biotechnologies, the operation of laboratories dedicated to life sciences and the role of venture capitalists (VCs) in front of the possibilities offered by the new technologies of genetic manipulation developed in the academic field. In particular, Powell and colleagues (Powell and Owen-Smith 2012; Powell and Sandholtz 2012a; Powell et al. 2012) analyzed the first generation of dedicated biotech firms (DBFs): these companies were founded by an amphibious scientist ‘who …