作者
Stergios A Polyzos, Konstantinos N Aronis, Jannis Kountouras, Dimitrios D Raptis, Maria F Vasiloglou, Christos S Mantzoros
发表日期
2016/1
来源
Diabetologia
卷号
59
页码范围
30-43
出版商
Springer Berlin Heidelberg
简介
Aims/hypothesis
Clinical data regarding circulating leptin levels in patients with non-alcoholic fatty liver disease (NAFLD) are conflicting. The purpose of this meta-analysis was to compare leptin levels between the following groups: patients with biopsy-proven NAFLD vs controls; simple steatosis (SS) patients vs controls; non-alcoholic steatohepatitis (NASH) patients vs controls and NASH patients vs SS patients.
Methods
We performed a systematic search in PubMed, Scopus and the Cochrane Library. We analysed 33 studies, published between 1999 and 2014, including 2,612 individuals (775 controls and 1,837 NAFLD patients).
Results
Higher circulating leptin levels were observed in NAFLD patients vs controls (standardised mean difference [SMD] 0.640; 95% CI 0.422, 0.858), SS patients vs controls (SMD 0.358; 95 …
学术搜索中的文章
SA Polyzos, KN Aronis, J Kountouras, DD Raptis… - Diabetologia, 2016