作者
Stergios A Polyzos, Jannis Kountouras, Athanasios Papatheodorou, Kalliopi Patsiaoura, Evangelia Katsiki, Efthimia Zafeiriadou, Christos Zavos, Kyriaki Anastasiadou, Evangelos Terpos
发表日期
2013/1/1
期刊
Metabolism
卷号
62
期号
1
页码范围
121-126
出版商
WB Saunders
简介
OBJECTIVE
Clinical data regarding Helicobacter pylori (Hp) infection in nonalcoholic fatty liver disease (NAFLD) are limited. The aim was the evaluation of Hp infection in patients with NAFLD and its association with disease severity.
METHODS
28 patients with biopsy-proven NAFLD (15 with simple nonalcoholic fatty liver [NAFL], 13 with nonalcoholic steatohepatitis [NASH]) and 25 matched healthy controls were recruited. Blood samples for anti-Hp Immunoglobulin G (IgG) and standard biochemical tests were obtained after overnight fasting, and 13C urea breath test was performed before liver biopsy in NAFLD group.
RESULTS
Higher rates of anti-Hp IgG (P=.038) were observed in NAFLD compared to control group. Only two NAFLD patients neither were Hp IgG seropositive nor did they have a history of eradication treatment compared to 11 control subjects (P=.002). Both Hp infection (assessed by history of Hp …
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SA Polyzos, J Kountouras, A Papatheodorou… - Metabolism, 2013