作者
Kirsten Seale, Steve Horvath, Andrew Teschendorff, Nir Eynon, Sarah Voisin
发表日期
2022/10
来源
Nature Reviews Genetics
卷号
23
期号
10
页码范围
585-605
出版商
Nature Publishing Group UK
简介
Over time, the human DNA methylation landscape accrues substantial damage, which has been associated with a broad range of age-related diseases, including cardiovascular disease and cancer. Various age-related DNA methylation changes have been described, including at the level of individual CpGs, such as differential and variable methylation, and at the level of the whole methylome, including entropy and correlation networks. Here, we review these changes in the ageing methylome as well as the statistical tools that can be used to quantify them. We detail the evidence linking DNA methylation to ageing phenotypes and the longevity strategies aimed at altering both DNA methylation patterns and machinery to extend healthspan and lifespan. Lastly, we discuss theories on the mechanistic causes of epigenetic ageing.
引用总数
学术搜索中的文章
K Seale, S Horvath, A Teschendorff, N Eynon, S Voisin - Nature Reviews Genetics, 2022