作者
Sara Hägg, Tove Fall, Alexander Ploner, Reedik Mägi, Krista Fischer, Harmen HM Draisma, Mart Kals, Paul S De Vries, Abbas Dehghan, Sara M Willems, Antti-Pekka Sarin, Kati Kristiansson, Marja-Liisa Nuotio, Aki S Havulinna, Renée FAG De Bruijn, M Arfan Ikram, Maris Kuningas, Bruno H Stricker, Oscar H Franco, Beben Benyamin, Christian Gieger, Alistair S Hall, Ville Huikari, Antti Jula, Marjo-Riitta Järvelin, Marika Kaakinen, Jaakko Kaprio, Michael Kobl, Massimo Mangino, Christopher P Nelson, Aarno Palotie, Nilesh J Samani, Tim D Spector, David P Strachan, Martin D Tobin, John B Whitfield, André G Uitterlinden, Veikko Salomaa, Ann-Christine Syvänen, Kari Kuulasmaa, Patrik K Magnusson, Tõnu Esko, Albert Hofman, Eco JC De Geus, Lars Lind, Vilmantas Giedraitis, Markus Perola, Alun Evans, Jean Ferrières, Jarmo Virtamo, Frank Kee, David-Alexandre Tregouet, Dominique Arveiler, Philippe Amouyel, Francesco Gianfagna, Paolo Brambilla, Samuli Ripatti, Cornelia M Van Duijn, Andres Metspalu, Inga Prokopenko, Mark I McCarthy, Nancy L Pedersen, Erik Ingelsson, European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium
发表日期
2015/4/1
期刊
International journal of epidemiology
卷号
44
期号
2
页码范围
578-586
出版商
Oxford University Press
简介
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods.
Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations of a genetic score (32 BMI single nucleotide polymorphisms) with BMI and cardiovascular outcomes were examined in up to 22 193 individuals with 3062 incident cardiovascular events from nine prospective follow-up studies within the ENGAGE consortium. We used random-effects meta-analysis in an MR framework to provide causal estimates of the effect of adiposity on cardiovascular outcomes.
Results: There was a strong association between BMI and incident CHD (HR = 1.20 …
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