作者
Alasdair PS Munro, Leila Janani, Victoria Cornelius, Parvinder K Aley, Gavin Babbage, David Baxter, Marcin Bula, Katrina Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Karishma Gokani, Anna L Goodman, Christopher A Green, Linda Harndahl, John Haughney, Alexander Hicks, Agatha A van der Klaauw, Jonathan Kwok, Teresa Lambe, Vincenzo Libri, Martin J Llewelyn, Alastair C McGregor, Angela M Minassian, Patrick Moore, Mehmood Mughal, Yama F Mujadidi, Jennifer Murira, Orod Osanlou, Rostam Osanlou, Daniel R Owens, Mihaela Pacurar, Adrian Palfreeman, Daniel Pan, Tommy Rampling, Karen Regan, Stephen Saich, Jo Salkeld, Dinesh Saralaya, Sunil Sharma, Ray Sheridan, Ann Sturdy, Emma C Thomson, Shirley Todd, Chris Twelves, Robert C Read, Sue Charlton, Bassam Hallis, Mary Ramsay, Nick Andrews, Jonathan S Nguyen-Van-Tam, Matthew D Snape, Xinxue Liu, Saul N Faust, Andrew Riordan, Andrew Ustianowski, Chris A Rogers, Stephen Hughes, Laura Longshaw, Jane Stockport, Rachel Hughes, Lynne Grundy, Lona Tudor Jones, Arpan Guha, Emma Snashall, Tom Eadsforth, Sally Reeder, Kim Storton, Malathi Munusamy, Bridget Tandy, Akamino Egbo, Stephen Cox, Nabeela Nazir Ahmed, Anil Shenoy, Rachel Bousfield, Donna Wixted, Helen Gutteridge, Becky Mansfield, Christopher Herbert, Kyra Holliday, James Calderwood, Dominique Barker, Jacqueline Brandon, Hayley Tulloch, Suzie Colquhoun, Helen Thorp, Helen Radford, Julie Evans, Helena Baker, Jeanette Thorpe, Sally Batham, Jessica Hailstone, Rachael Phillips, Dileep Kumar, Fran Westwell, Fiona Makia, NinaSimone Hopkins, Lara Barcella, Mushiya Mpelembue, Olumide Adebambo, Sunder Chita, Tumena Corrah, Ashley Whittington, Laurence John, Siobhan Roche, Lynda Wagstaff, Adam Farrier, Karen Bisnauthsing, Teona Serafimova, Elisa Nanino, Enya Cooney, Jaimie Wilson-Goldsmith, Hanna Nguyen, Andrea Mazzella, Beth Jackson, Suahil Aslam, Tanveer Bawa, Samantha Broadhead, Sadaf Farooqi, Jo Piper, Rowena Weighell, Lorinda Pickup, Djamila Shamtally, Jason Domingo, Evgenia Kourampa, Colin Hale, Jennifer Gibney, Michael Stackpoole, Zalina Rashid-Gardner, Rebecca Lyon, Chloe McDonnell, Christine Cole, Anna Stewart, Gillian McMillan, Mary Savage, Helen Beckett, Chantelle Moorbey, Amisha Desai, Claire Brown, Kush Naker, Ehsaan Qureshi, Charlotte Trinham, Charlotte Sabine, Sophie Moore, Steve Hurdover, Edwin Justice, David Smith, Emma Plested, Carla Ferreira Da Silva, Rachel White
发表日期
2021/12/18
期刊
The Lancet
卷号
398
期号
10318
页码范围
2258-2276
出版商
Elsevier
简介
Background
Few data exist on the comparative safety and immunogenicity of different COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of booster vaccines, we investigated the reactogenicity and immunogenicity of seven different COVID-19 vaccines as a third dose after two doses of ChAdOx1 nCov-19 (Oxford–AstraZeneca; hereafter referred to as ChAd) or BNT162b2 (Pfizer–BioNtech, hearafter referred to as BNT).
Methods
COV-BOOST is a multicentre, randomised, controlled, phase 2 trial of third dose booster vaccination against COVID-19. Participants were aged older than 30 years, and were at least 70 days post two doses of ChAd or at least 84 days post two doses of BNT primary COVID-19 immunisation course, with no history of laboratory-confirmed SARS-CoV-2 infection. 18 sites were split into three groups (A, B, and C). Within each site group (A, B, or C …
学术搜索中的文章
APS Munro, L Janani, V Cornelius, PK Aley… - The Lancet, 2021