作者
Tom Alber, Sun Dao-Pin, Keith Wilson, Joan A Wozniak, Sean P Cook, Brian W Matthews
发表日期
1987/11/5
期刊
Nature
卷号
330
期号
6143
页码范围
41-46
出版商
Nature Publishing Group UK
简介
Measurements of changes in structure and stability caused by 13 different substitutions for threonine 157 in phage T4 lysozyme show that the most stable lysozyme variants contain hydrogen bonds analogous to those in the wild-type enzyme and that structural adjustments allow the protein to be surprisingly tolerant of amino-acid substitutions.
引用总数
学术搜索中的文章
T Alber, S Dao-Pin, K Wilson, JA Wozniak, SP Cook… - Nature, 1987