作者
Chi-Kuei Hsu, Ching-Yi Chen, Wang-Chun Chen, Chien-Ming Chao, Chih-Cheng Lai
发表日期
2022/3/4
来源
Expert Review of Anti-infective Therapy
卷号
20
期号
3
页码范围
435-444
出版商
Taylor & Francis
简介
Background
This systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of novel lipoglycopeptides in treating acute bacterial skin and skin structure infections (ABSSSIs).
Research design and methods
PubMed, Embase, Cochrane Central Register of Controlled Trials, Turning Research into Practice, and ClinicalTrials.gov were searched from inception to 20 May 2021. Randomized controlled trials (RCTs) comparing the clinical efficacy and safety of lipoglycopeptides with other comparators in treating adult patients with ABSSSIs were included. The primary outcome was clinical response.
Results
Eight RCTs (6416 patients; lipoglycopeptides: 3359, comparators: 3057) were enrolled. Clinical response rate was not significantly different between lipoglycopeptides and comparators at early-clinical-evaluation (odds ratio [95% confidence interval]: 1.01 [0.85–1.20], I2 = 34%), end-of …
学术搜索中的文章
CK Hsu, CY Chen, WC Chen, CM Chao, CC Lai - Expert Review of Anti-infective Therapy, 2022