作者
Ziver Sahin, Muge Bıcakcıgil, Kenan Aksu, Sevil Kamali, Servet Akar, Fatos Onen, Omer Karadag, Zeynep Ozbalkan, Askin Ates, Huseyin TE Ozer, Vuslat Yilmaz, Emire Seyahi, Mehmet A Ozturk, Ayse Cefle, Veli Cobankara, A Mesut Onat, Ercan Tunc, Nursen Düzgün, Sibel Z Aydin, Neslihan Yilmaz, İzzet Fresko, Yasar Karaaslan, Sedat Kiraz, Nurullah Akkoc, Murat Inanc, Gokhan Keser, F Aytul Uyar, Haner Direskeneli, Güher Saruhan-Direskeneli, Turkish Takayasu Study Group
发表日期
2012/2
期刊
Arthritis research & therapy
卷号
14
页码范围
1-5
出版商
BioMed Central
简介
Introduction
HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and severity factors.
Methods
TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by using PCR with sequence-specific primers …
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