作者
Paul A Renauer, Guher Saruhan‐Direskeneli, Patrick Coit, Adam Adler, Kenan Aksu, Gokhan Keser, Fatma Alibaz‐Oner, Sibel Z Aydin, Sevil Kamali, Murat Inanc, Simon Carette, David Cuthbertson, Gary S Hoffman, Servet Akar, Fatos Onen, Nurullah Akkoc, Nader A Khalidi, Curry Koening, Omer Karadag, Sedat Kiraz, Carol A Langford, Kathleen Maksimowicz‐McKinnon, Carol A McAlear, Zeynep Ozbalkan, Askin Ates, Yasar Karaaslan, Nursen Duzgun, Paul A Monach, Huseyin TE Ozer, Eren Erken, Mehmet A Ozturk, Ayten Yazici, Ayse Cefle, Ahmet Mesut Onat, Bunyamin Kisacik, Christian Pagnoux, Timucin Kasifoglu, Emire Seyahi, Izzet Fresko, Philip Seo, Antoine G Sreih, Kenneth J Warrington, Steven R Ytterberg, Veli Cobankara, Deborah S Cunninghame‐Graham, Timothy J Vyse, Omer N Pamuk, S Ercan Tunc, Ediz Dalkilic, Muge Bicakcigil, Sibel P Yentur, Jonathan D Wren, Peter A Merkel, Haner Direskeneli, Amr H Sawalha
发表日期
2015/5
期刊
Arthritis & rheumatology
卷号
67
期号
5
页码范围
1361-1368
简介
Objective
Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome‐wide association analysis of Takayasu arteritis.
Methods
Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1,047 controls of European ancestry. Genotyping was performed using the Omni1‐Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis.
Results
We identified genetic susceptibility loci for Takayasu arteritis with a genome‐wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10−9), RPS9 …
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PA Renauer, G Saruhan‐Direskeneli, P Coit, A Adler… - Arthritis & rheumatology, 2015