作者
Shelly J Krebs, Young D Kwon, Chaim A Schramm, William H Law, Gina Donofrio, Kenneth H Zhou, Syna Gift, Vincent Dussupt, Ivelin S Georgiev, Sebastian Schätzle, Jonathan R McDaniel, Yen-Ting Lai, Mallika Sastry, Baoshan Zhang, Marissa C Jarosinski, Amy Ransier, Agnes L Chenine, Mangaiarkarasi Asokan, Robert T Bailer, Meera Bose, Alberto Cagigi, Evan M Cale, Gwo-Yu Chuang, Samuel Darko, Jefferson I Driscoll, Aliaksandr Druz, Jason Gorman, Farida Laboune, Mark K Louder, Krisha McKee, Letzibeth Mendez, M Anthony Moody, Anne Marie O’Sullivan, Christopher Owen, Dongjun Peng, Reda Rawi, Eric Sanders-Buell, Chen-Hsiang Shen, Andrea R Shiakolas, Tyler Stephens, Yaroslav Tsybovsky, Courtney Tucker, Raffaello Verardi, Keyun Wang, Jing Zhou, Tongqing Zhou, George Georgiou, S Munir Alam, Barton F Haynes, Morgane Rolland, Gary R Matyas, Victoria R Polonis, Adrian B McDermott, Daniel C Douek, Lawrence Shapiro, Sodsai Tovanabutra, Nelson L Michael, John R Mascola, Merlin L Robb, Peter D Kwong, Nicole A Doria-Rose
发表日期
2019/3/19
期刊
Immunity
卷号
50
期号
3
页码范围
677-691. e13
出版商
Cell Press
简介
Lineage-based vaccine design is an attractive approach for eliciting broadly neutralizing antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied to date have features indicative of unusual recombination and/or development. From an individual in the prospective RV217 cohort, we identified three lineages of bNAbs targeting the membrane-proximal external region (MPER) of the HIV-1 envelope. Antibodies RV217-VRC42.01, -VRC43.01, and -VRC46.01 used distinct modes of recognition and neutralized 96%, 62%, and 30%, respectively, of a 208-strain virus panel. All three lineages had modest levels of somatic hypermutation and normal antibody-loop lengths and were initiated by the founder virus MPER. The broadest lineage, VRC42, was similar to the known bNAb 4E10. A multimeric immunogen based on the founder MPER activated B cells bearing the unmutated common ancestor of VRC42 …
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SJ Krebs, YD Kwon, CA Schramm, WH Law… - Immunity, 2019