作者
Nicole A Doria-Rose, Chaim A Schramm, Jason Gorman, Penny L Moore, Jinal N Bhiman, Brandon J DeKosky, Michael J Ernandes, Ivelin S Georgiev, Helen J Kim, Marie Pancera, Ryan P Staupe, Han R Altae-Tran, Robert T Bailer, Ema T Crooks, Albert Cupo, Aliaksandr Druz, Nigel J Garrett, Kam H Hoi, Rui Kong, Mark K Louder, Nancy S Longo, Krisha McKee, Molati Nonyane, Sijy O’Dell, Ryan S Roark, Rebecca S Rudicell, Stephen D Schmidt, Daniel J Sheward, Cinque Soto, Constantinos Kurt Wibmer, Yongping Yang, Zhenhai Zhang, NISC Comparative Sequencing, James C Mullikin, James M Binley, Rogier W Sanders, Ian A Wilson, John P Moore, Andrew B Ward, George Georgiou, Carolyn Williamson, Salim S Abdool Karim, Lynn Morris, Peter D Kwong, Lawrence Shapiro, John R Mascola
发表日期
2014/5/1
期刊
Nature
卷号
509
期号
7498
页码范围
55-62
出版商
Nature Publishing Group
简介
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the developmental pathway by which such antibodies are generated and acquire the requisite molecular characteristics for neutralization. Twelve somatically related neutralizing antibodies (CAP256-VRC26.01–12) were isolated from donor CAP256 (from the Centre for the AIDS Programme of Research in South Africa (CAPRISA)); each antibody contained the protruding tyrosine-sulphated, anionic antigen-binding loop (complementarity-determining region (CDR) H3) characteristic of this category of antibodies. Their unmutated ancestor emerged between weeks 30–38 post-infection with a 35-residue CDR H3, and neutralized the virus that superinfected this individual 15 weeks after initial infection. Improved neutralization breadth and …
学术搜索中的文章
NA Doria-Rose, CA Schramm, J Gorman, PL Moore… - Nature, 2014