作者
Kizzmekia S Corbett, Matthew Gagne, Danielle A Wagner, Sarah O’Connell, Sandeep R Narpala, Dillon R Flebbe, Shayne F Andrew, Rachel L Davis, Barbara Flynn, Timothy S Johnston, Christopher D Stringham, Lilin Lai, Daniel Valentin, Alex Van Ry, Zackery Flinchbaugh, Anne P Werner, Juan I Moliva, Manjari Sriparna, Sijy O’Dell, Stephen D Schmidt, Courtney Tucker, Angela Choi, Matthew Koch, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, Gabriela S Alvarado, Amy R Henry, Farida Laboune, Chaim A Schramm, Yi Zhang, Eun Sung Yang, Lingshu Wang, Misook Choe, Seyhan Boyoglu-Barnum, Shi Wei, Evan Lamb, Saule T Nurmukhambetova, Samantha J Provost, Mitzi M Donaldson, Josue Marquez, John-Paul M Todd, Anthony Cook, Alan Dodson, Andrew Pekosz, Eli Boritz, Aurélie Ploquin, Nicole Doria-Rose, Laurent Pessaint, Hanne Andersen, Kathryn E Foulds, John Misasi, Kai Wu, Andrea Carfi, Martha C Nason, John Mascola, Ian N Moore, Darin K Edwards, Mark G Lewis, Mehul S Suthar, Mario Roederer, Adrian McDermott, Daniel C Douek, Nancy J Sullivan, Barney S Graham, Robert A Seder
发表日期
2021/12/10
期刊
Science
卷号
374
期号
6573
页码范围
1343-1353
出版商
American Association for the Advancement of Science
简介
Neutralizing antibody responses gradually wane against several variants of concern (VOCs) after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine messenger RNA-1273 (mRNA-1273). We evaluated the immune responses in nonhuman primates that received a primary vaccination series of mRNA-1273 and were boosted about 6 months later with either homologous mRNA-1273 or heterologous mRNA-1273.β, which encompasses the spike sequence of the B.1.351 Beta variant. After boost, animals had increased neutralizing antibody responses across all VOCs, which was sustained for at least 8 weeks after boost. Nine weeks after boost, animals were challenged with the SARS-CoV-2 Beta variant. Viral replication was low to undetectable in bronchoalveolar lavage and significantly reduced in nasal swabs in all boosted animals, suggesting that booster vaccinations …
学术搜索中的文章
KS Corbett, M Gagne, DA Wagner, S O'Connell… - Science, 2021
KS Corbett, M Gagne, DA Wagner, SO Connell… - bioRxiv, 2021