作者
Tongqing Zhou, Jiang Zhu, Xueling Wu, Stephanie Moquin, Baoshan Zhang, Priyamvada Acharya, Ivelin S Georgiev, Han R Altae-Tran, Gwo-Yu Chuang, M Gordon Joyce, Young Do Kwon, Nancy S Longo, Mark K Louder, Timothy Luongo, Krisha McKee, Chaim A Schramm, Jeff Skinner, Yongping Yang, Zhongjia Yang, Zhenhai Zhang, Anqi Zheng, Mattia Bonsignori, Barton F Haynes, Johannes F Scheid, Michel C Nussenzweig, Melissa Simek, Dennis R Burton, Wayne C Koff, James C Mullikin, Mark Connors, Lawrence Shapiro, Gary J Nabel, John R Mascola, Peter D Kwong
发表日期
2013/8/22
期刊
Immunity
卷号
39
期号
2
页码范围
245-258
出版商
Cell Press
简介
Antibodies of the VRC01 class neutralize HIV-1, arise in diverse HIV-1-infected donors, and are potential templates for an effective HIV-1 vaccine. However, the stochastic processes that generate repertoires in each individual of >1012 antibodies make elicitation of specific antibodies uncertain. Here we determine the ontogeny of the VRC01 class by crystallography and next-generation sequencing. Despite antibody-sequence differences exceeding 50%, antibody-gp120 cocrystal structures reveal VRC01-class recognition to be remarkably similar. B cell transcripts indicate that VRC01-class antibodies require few specific genetic elements, suggesting that naive-B cells with VRC01-class features are generated regularly by recombination. Virtually all of these fail to mature, however, with only a few—likely one—ancestor B cell expanding to form a VRC01-class lineage in each donor. Developmental similarities in …
学术搜索中的文章
T Zhou, J Zhu, X Wu, S Moquin, B Zhang, P Acharya… - Immunity, 2013