作者
Shea J Andrews, Brian Fulton‐Howard, Paul O'Reilly, Edoardo Marcora, Alison M Goate, collaborators of the Alzheimer's Disease Genetics Consortium, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Adam C Naj, Margaret A Pericak‐Vance, Gerard D Schellenberg, Li‐San Wang
发表日期
2021/1
期刊
Annals of neurology
卷号
89
期号
1
页码范围
54-65
出版商
John Wiley & Sons, Inc.
简介
Objective
The purpose of this study was to infer causal relationships between 22 previously reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of onset (AAOS), hippocampal volume, cortical surface area and thickness, cerebrospinal fluid (CSF) levels of amyloid‐β (Aβ42), tau, and ptau181, and the neuropathological burden of neuritic plaques, neurofibrillary tangles (NFTs), and vascular brain injury (VBI).
Methods
Polygenic risk scores (PRS) for the 22 risk factors were computed in 26,431 AD cases/controls and the association with AD was evaluated using logistic regression. Two‐sample Mendelian randomization (MR) was used to infer the causal effect of risk factors on the AD phenome.
Results
PRS for increased education and diastolic blood pressure were associated with reduced risk for AD. MR indicated that only education was causally associated with reduced risk of AD …
学术搜索中的文章
SJ Andrews, B Fulton‐Howard, P O'Reilly, E Marcora… - Annals of neurology, 2021