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This paper reports on an algorithm for automatic, targetless, extrinsic calibration of a lidar and optical camera system based upon the maximization of mutual information between the sensor‐measured surface intensities. The proposed method is completely data‐driven and does not require any fiducial calibration targets—making in situ calibration easy. We calculate the Cramér‐Rao lower bound (CRLB) of the estimated calibration parameter variance, and we show experimentally that the sample variance of the estimated parameters empirically approaches the CRLB when the amount of data used for calibration is sufficiently large. Furthermore, we compare the calibration results to independent ground‐truth (where available) and observe that the mean error empirically approaches zero as the amount of data used for calibration is increased, thereby suggesting that the proposed estimator is a minimum variance …