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The industrial Internet of Things (IIoT) has gained more attention because of the self-governing nature of system configuration with interoperable application connectivity. In the E-healthcare environment, it cooperates with medical sensors to capture, examine, analyze, preserve, and document day-to-day transactions of patients in real-time. The integration of E-healthcare and IIoT provides an analytical platform to handle a large amount of data with a low cost of cloud-enabling scalable storage. Throughout the transformation, patients’ personal information is at risk while exchanging records over centralized server-based systems. Thus, the rate of node connectivity, failure of parallel data sharing, and deliverance-related issues increase. In this article, we present solutions in three folds. First, the article proposes a novel and secure architecture for E-healthcare data security using a blockchain-distributed ledger …