作者
Tatiane Renata Fagundes, Aedra Carla Bufalo Kawassaki, Virginia Marcia Concato, João Paulo Assolini, Taylon Felipe Silva, Manoela Daiele Gonçalves, Elaine da Silva Siqueira, Claudia Stoeglehner Sahd, Fabrício Seidy Ribeiro Inoue, Thais Peron da Silva, Debora Messagi de Lima, Mariane Okamoto Ferreira, Ivete Conchon-Costa, Wander Rogério Pavanelli, Carolina Panis
发表日期
2023/4/5
图书
Handbook of Cancer and Immunology
页码范围
1-30
出版商
Springer International Publishing
简介
Pesticides are chemicals used extensively throughout the agricultural sector to control pests, such as insects, that commonly attack and destroy crops. In recent years, their use has increased considerably, in which humans are exposed to pesticides in their occupations or through dietary and environmental exposure. The WHO has suggested that more than three million pesticide-induced poisonings occur annually, resulting in deaths and diseases. Clinical studies with humans and experimental animal models have shown that exposure to pesticides interferes in several endocrine pathways related to the activation of survival, proliferation, and differentiation of stem cells and can be strictly related to several other diseases, such as cancer. Long-term exposure to pesticides can cause immune dysregulation, and their effects depend on the type of chemical substance, dosage, route, and duration of exposure. Immune …
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