作者
Joseph C Kolars, Paul B Watkins, Robert M Merion, WM Awni
发表日期
1991/12/14
期刊
The Lancet
卷号
338
期号
8781
页码范围
1488-1490
出版商
Elsevier
简介
Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.
引用总数
学术搜索中的文章
JC Kolars, PB Watkins, RM Merion, WM Awni - The Lancet, 1991