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The VHCF behaviors of an extruded magnesium alloy are investigated. Due to the microstructure inhomogeneity, fatigue damages prefer to concentrate in the few larger grains. Basal slip deformations are supposed to be responsible for the transgranular crack initiations, and form the similar faceted morphologies. Under same stress amplitude, internal failures present longer fatigue lives than surface failures due to the requirement of larger initial crack and the deceleration rate in the vacuum-like environment at specimen interior.