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Metabolism diseases are evaluated by using a sensor to measure concentration of a medically significant analyte in a human or animal body fluid. The measurement data are correlated with the concentration of a medically significant analyte in body fluid over a time period of at least eight hours. An analytical facility analyzes time intervals within the time period to determine a stability parameter that characterizes the analyte concentration dynamics of change. The analytical facility further analyzes the stability parameters to determine disease-related particularities of metabolism.