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Mammography is the best available tool for screening for the early detection of breast cancer. Mammographic screening has been shown to be effective in reducing breast cancer mortality rates: screening programs have reduced mortality rates by 30–70%. Mammograms are difficult to interpret, especially in the screening context. The sensitivity of screening mammography is affected by image quality and the radiologist's level of expertise. Computer-aided diagnosis (CAD) technology can improve the performance of radiologists, by increasing sensitivity to rates comparable to those obtained by double reading, in a cost-effective manner. Current research is directed toward the development of digital imaging and image analysis systems that can detect mammographic features, classify them, and provide visual prompts to the radiologist. Radiologists would like the ability to change the contrast of a mammogram, either …