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Background. Tissue damage caused by COVID‐19 could be detected by several clinical indicators including hematological, immunological, biochemical, and inflammatory markers. This study was to detect these clinical parameters to reveal the correlation between the factors and their roles in the development of COVID‐19, to explore the hazard factors in severe cases. Materials and Methods. A total of 200 participants of both sexes were included in the study, with an age range of (25–72) years, categorized into three main groups: 50 healthy individuals, 62 mild infected patients, and 88 severe infected patients with pneumonia. Different hematological and clinical parameters were included in the analysis (Basrah city, Iraq). Serum levels of interleukin‐6 (IL‐6), ferritin, and high‐sensitivity C‐reactive protein (hs‐CRP) were assessed for all participants using an enzyme‐linked immunosorbent assay (ELISA). The liver …