作者
Ali Abbara, Pei Chia Eng, Maria Phylactou, Sophie A Clarke, Edouard Mills, Germaine Chia, Lisa Yang, Chioma Izzi-Engbeaya, Neil Smith, Channa N Jayasena, Alexander N Comninos, Ravinder Anand-Ivell, Jesse Rademaker, Cheng Xu, Richard Quinton, Nelly Pitteloud, Waljit S Dhillo
发表日期
2021/11/9
期刊
Neuroendocrinology
卷号
111
期号
12
页码范围
1176-1186
出版商
S. Karger AG
简介
Background
Hypogonadotropic hypogonadism (HH) is hypogonadism due to either hypothalamic or pituitary dysfunction. While gonadotropin-releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic GnRH release and thus could be used to specifically interrogate hypothalamic function. Congenital HH (CHH) is typically due to variants in genes that control hypothalamic GnRH neuronal migration or function. Thus, we investigated whether KP54 could accurately identify hypothalamic dysfunction in men with CHH. Methods
Men with CHH (n= 21) and healthy eugonadal men (n= 21) received an intravenous bolus of either GnRH (100 μg) or KP54 (6.4 nmol/kg), on 2 occasions, and were monitored for 6 h after administration of each neuropeptide. Results
Maximal luteinizing hormone (LH …学术搜索中的文章
A Abbara, PC Eng, M Phylactou, SA Clarke, E Mills… - Neuroendocrinology, 2021