作者
Chioma Izzi-Engbeaya, Sophie Jones, Yoshibye Crustna, Pratibha C Machenahalli, Deborah Papadopoulou, Manish Modi, Christos Panayi, Jessica Starikova, Pei Chia Eng, Maria Phylactou, Edouard Mills, Lisa Yang, Risheka Ratnasabapathy, Mark Sykes, Isabella Plumptre, Ben Coumbe, Victoria C Wing, Ewa Pacuszka, Paul Bech, James Minnion, George Tharakan, Tricia Tan, Johannes Veldhuis, Ali Abbara, Alexander N Comninos, Waljit S Dhillo
发表日期
2020/4
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
105
期号
4
页码范围
1119-1125
出版商
Oxford University Press
简介
Context
Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans.
Objective
To investigate the effects of GLP-1 administration on the reproductive axis in humans.
Design
Single-blind, randomized, placebo-controlled crossover study.
Setting
Clinical Research Facility, Imperial College Healthcare NHS Trust.
Participants
Eighteen healthy men (mean age 24.7 ± 0.1years, mean BMI 22.1 ± 0.4kg/m2).
Intervention
Eight-hour intravenous infusion of 0.8 pmol/kg/min GLP-1 or rate …
学术搜索中的文章
C Izzi-Engbeaya, S Jones, Y Crustna, PC Machenahalli… - The Journal of Clinical Endocrinology & Metabolism, 2020