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The global COVID-19 pandemic is affecting people’s work-life balance across the world. For academics, confinement policies enacted by most countries have implied a sudden switch to home-work, a transition to online teaching and mentoring, and an adjustment of research activities. In this article we discuss how the COVID-19 crisis is affecting our profession and how it may change it in the future. We argue that academia must foster a culture of care, help us refocus on what is most important, and redefine excellence in teaching and research. Such re-orientation can make academic practice more respectful and sustainable, now during confinement but also once the pandemic has passed. We conclude providing practical suggestions on how to renew our practice, which inevitably entails re-assessing the social-psychological, political, and environmental implications of academic activities and our value systems.