作者
Sanjit S Jolly, John A Cairns, Salim Yusuf, Brandi Meeks, Janice Pogue, Michael J Rokoss, Sasko Kedev, Lehana Thabane, Goran Stankovic, Raul Moreno, Anthony Gershlick, Saqib Chowdhary, Shahar Lavi, Kari Niemelä, Philippe Gabriel Steg, Ivo Bernat, Yawei Xu, Warren J Cantor, Christopher B Overgaard, Christoph K Naber, Asim N Cheema, Robert C Welsh, Olivier F Bertrand, Alvaro Avezum, Ravinay Bhindi, Samir Pancholy, Sunil V Rao, Madhu K Natarajan, Jurriën M ten Berg, Olga Shestakovska, Peggy Gao, Petr Widimsky, Vladimír Džavík
发表日期
2015/4/9
期刊
New England Journal of Medicine
卷号
372
期号
15
页码范围
1389-1398
出版商
Massachusetts Medical Society
简介
Background
During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested that thrombectomy improves surrogate and clinical outcomes, but a larger trial has reported conflicting results.
Methods
We randomly assigned 10,732 patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI to a strategy of routine upfront manual thrombectomy versus PCI alone. The primary outcome was a composite of death from cardiovascular causes, recurrent myocardial infarction, cardiogenic shock, or New York Heart Association (NYHA) class IV heart failure within 180 days. The key safety outcome was stroke within 30 days.
Results
The primary outcome occurred in 347 of 5033 patients (6.9%) in the thrombectomy group versus 351 of 5030 patients (7.0%) in the PCI-alone …
学术搜索中的文章
SS Jolly, JA Cairns, S Yusuf, B Meeks, J Pogue… - New England Journal of Medicine, 2015