作者
Sanjit S Jolly, Stefan James, Vladimír Džavík, John A Cairns, Karim D Mahmoud, Felix Zijlstra, Salim Yusuf, Goran K Olivecrona, Henrik Renlund, Peggy Gao, Bo Lagerqvist, Ashraf Alazzoni, Sasko Kedev, Goran Stankovic, Brandi Meeks, Ole Frøbert
发表日期
2017/1/10
期刊
Circulation
卷号
135
期号
2
页码范围
143-152
出版商
Lippincott Williams & Wilkins
简介
Background
Thrombus aspiration during percutaneous coronary intervention (PCI) for the treatment of ST-segment–elevation myocardial infarction (STEMI) has been widely used; however, recent trials have questioned its value and safety. In this meta-analysis, we, the trial investigators, aimed to pool the individual patient data from these trials to determine the benefits and risks of thrombus aspiration during PCI in patients with ST-segment–elevation myocardial infarction.
Methods
Included were large (n≥1000), randomized, controlled trials comparing manual thrombectomy and PCI alone in patients with ST-segment–elevation myocardial infarction. Individual patient data were provided by the leadership of each trial. The prespecified primary efficacy outcome was cardiovascular mortality within 30 days, and the primary safety outcome was stroke or transient ischemic attack within 30 days.
Results
The 3 eligible …
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SS Jolly, S James, V Džavík, JA Cairns, KD Mahmoud… - Circulation, 2017