作者
Guido J Falcone, Elayna Kirsch, Julian N Acosta, Rommell B Noche, Audrey Leasure, Sandro Marini, Jaeyoon Chung, Magdy Selim, James F Meschia, Devin L Brown, Bradford B Worrall, David L Tirschwell, Jeremiasz M Jagiella, Helena Schmidt, Jordi Jimenez‐Conde, Israel Fernandez‐Cadenas, Arne Lindgren, Agnieszka Slowik, Dipender Gill, Michael Holmes, Chia‐Ling Phuah, Nils H Petersen, Charles N Matouk, MD, Murat Gunel, Lauren Sansing, Derrick Bennett, Zhengming Chen, Luan L Sun, Robert Clarke, Robin G Walters, Thomas M Gill, Alessandro Biffi, Sekar Kathiresan, Carl D Langefeld, Daniel Woo, Jonathan Rosand, Kevin N Sheth, Christopher D Anderson, International Stroke Genetics Consortium
发表日期
2020/7
期刊
Annals of neurology
卷号
88
期号
1
页码范围
56-66
出版商
John Wiley & Sons, Inc.
简介
Objective
Observational studies point to an inverse correlation between low‐density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically elevated LDL is associated with reduced risk of ICH.
Methods
We constructed one polygenic risk score (PRS) per lipid trait (total cholesterol, LDL, high‐density lipoprotein [HDL], and triglycerides) using independent genomewide significant single nucleotide polymorphisms (SNPs) for each trait. We used data from 316,428 individuals enrolled in the UK Biobank to estimate the effect of each PRS on its corresponding trait, and data from 1,286 ICH cases and 1,261 matched controls to estimate the effect of each PRS on ICH risk. We used these estimates to conduct Mendelian Randomization (MR) analyses.
Results
We identified 410, 339, 393, and 317 …
学术搜索中的文章
GJ Falcone, E Kirsch, JN Acosta, RB Noche, A Leasure… - Annals of neurology, 2020