作者
Nathaniel A Cohen, Tamar Miller, Wasef Na’aminh, Keren Hod, Amos Adler, Daniel Cohen, Hanan Guzner-Gur, Erwin Santo, Zamir Halpern, Yehuda Carmeli, Nitsan Maharshak
发表日期
2018/6
期刊
United European gastroenterology journal
卷号
6
期号
5
页码范围
773-780
出版商
SAGE Publications
简介
Background
Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins.
Objective
The objective of this article is to determine whether fecal C. difficile toxin (CDT) levels are associated with disease severity and prognosis.
Methods
A cross-sectional study of patients admitted with CDI in a tertiary center between 2011 and 2015 was conducted. Fecal CDT levels were determined by quantitative ELISA. Severe CDI was defined as a leukocyte count of > 15 × 103 cells/μl, creatinine levels that deteriorated by > 1.5 times the baseline level, or albumin levels < 3 g/dl.
Results
Seventy-three patients were recruited for this study. Patients with severe CDI (n = 47) had significantly higher toxin levels …
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NA Cohen, T Miller, W Na'aminh, K Hod, A Adler… - United European gastroenterology journal, 2018