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This study aims to identify effective predictors that influence publics’ emotional reactions to COVID-19 vaccine misinformation as well as corrective messages. We collected a large sample of COVID-19 vaccine related misinformation and corrective messages on Facebook as well as the users’ emotional reactions (i.e., emojis) to these messages. Focusing on three clusters of features such as messages’ linguistic features, source characteristics, and messages’ network positions, we examined whether users’ reactions to misinformation and corrective information would differ. We used random forest models to identify the most salient predictors among over 70 predictors for both types of messages. Our analysis found that for misinformation, political ideology of the message source was the most salient feature that predicted anxious and enthusiastic reactions, followed by message features that highlight personal …