作者
James A Sanford, Christopher D Nogiec, Malene E Lindholm, Joshua N Adkins, David Amar, Surendra Dasari, Jonelle K Drugan, Facundo M Fernández, Shlomit Radom-Aizik, Simon Schenk, Michael P Snyder, Russell P Tracy, Patrick Vanderboom, Scott Trappe, Martin J Walsh, Charles R Evans, Facundo M Fernandez, Yafeng Li, Lyl Tomlinson, D Lee Alekel, Iddil Bekirov, Amanda T Boyce, Josephine Boyington, Jerome L Fleg, Lyndon JO Joseph, Maren R Laughlin, Padma Maruvada, Stephanie A Morris, Joan A McGowan, Concepcion Nierras, Vinay Pai, Charlotte Peterson, Ed Ramos, Mary C Roary, John P Williams, Ashley Xia, Elaine Cornell, Jessica Rooney, Michael E Miller, Walter T Ambrosius, Scott Rushing, Cynthia L Stowe, W Jack Rejeski, Barbara J Nicklas, Marco Pahor, Ching-ju Lu, Todd Trappe, Toby Chambers, Ulrika Raue, Bridget Lester, Bryan C Bergman, David H Bessesen, Catherine M Jankowski, Wendy M Kohrt, Edward L Melanson, Kerrie L Moreau, Irene E Schauer, Robert S Schwartz, William E Kraus, Cris A Slentz, Kim M Huffman, Johanna L Johnson, Leslie H Willis, Leslie Kelly, Joseph A Houmard, Gabriel Dubis, Nick Broskey, Bret H Goodpaster, Lauren M Sparks, Paul M Coen, Dan M Cooper, Fadia Haddad, Tuomo Rankinen, Eric Ravussin, Neil Johannsen, Melissa Harris, John M Jakicic, Anne B Newman, Daniel D Forman, Erin Kershaw, Renee J Rogers, Bradley C Nindl, Lindsay C Page, Maja Stefanovic-Racic, Susan L Barr, Blake B Rasmussen, Tatiana Moro, Doug Paddon-Jones, Elena Volpi, Heidi Spratt, Nicolas Musi, Sara Espinoza, Darpan Patel, Monica Serra, Jonathan Gelfond, Aisling Burns, Marcas M Bamman, Thomas W Buford, Gary R Cutter, Sue C Bodine, Karyn Esser, Rodger P Farrar, Laurie J Goodyear, Michael F Hirshman, Brent G Albertson, Wei-Jun Qian, Paul Piehowski, Marina A Gritsenko, Matthew E Monore, Vladislav A Petyuk, Jason E McDermott, Joshua N Hansen, Chelsea Hutchison, Samuel Moore, David A Gaul, Clary B Clish, Julian Avila-Pacheco, Courtney Dennis, Manolis Kellis, Steve Carr, Pierre M Jean-Beltran, Hasmik Keshishian, DR Mani, Karl Clauser, Karsten Krug, Charlie Mundorff, Cadence Pearce, Anna A Ivanova, Eric A Ortlund, Kristal Maner-Smith, Karan Uppal, Tiantian Zhang, Stuart C Sealfon, Elena Zaslavsky, Venugopalan Nair, SiDe Li, Nimisha Jain, YongChao Ge, Yifei Sun, German Nudelman, Frederique Ruf-zamojski, Gregory Smith, Nhanna Pincas, Aliza Rubenstein, Mary Anne Amper, Nitish Seenarine, Tuuli Lappalainen, Ian R Lanza, K Sreekumaran Nair, Katherine Klaus
发表日期
2020/6/25
来源
Cell
卷号
181
期号
7
页码范围
1464-1474
出版商
Elsevier
简介
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is …
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JA Sanford, CD Nogiec, ME Lindholm, JN Adkins… - Cell, 2020