作者
Rui Li, Xizhen Xu, Chen Chen, Xuefeng Yu, Matthew L Edin, Laura Miller Degraff, Craig R Lee, Darryl C Zeldin, Dao Wen Wang
发表日期
2012/12/1
期刊
Prostaglandins & other lipid mediators
卷号
99
期号
3-4
页码范围
68-78
出版商
Elsevier
简介
Cytochrome P450 epoxygenase metabolites of arachidonic acid, EETs, have multiple cardiovascular effects, including reduction of blood pressure, protection against myocardial ischemia-reperfusion injury, and attenuation of endothelial apoptosis. This study investigated the hypothesis that transgenic mice with endothelial overexpression of CYP2J2 (Tie2-CYP2J2-Tr) would be protected against global cerebral ischemia induced by bilateral common carotid artery occlusion (BCCAO) and action mechanisms of EETs on cerebral ischemia in cultures of astrocytes exposed to oxygen–glucose deprivation (OGD). Tie2-CYP2J2-Tr mice had significantly increased CYP2J2 expression, increased 14,15-EET production, increases regional cerebral blood flow (rCBF) and microvascular density, decreased ROS production, decreased brain infarct size and apoptosis after ischemia compared to wild type mice, these were …
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R Li, X Xu, C Chen, X Yu, ML Edin, LM Degraff, CR Lee… - Prostaglandins & other lipid mediators, 2012