作者
Nuno R Faria, Thomas A Mellan, Charles Whittaker, Ingra M Claro, Darlan da S Candido, Swapnil Mishra, Myuki AE Crispim, Flavia CS Sales, Iwona Hawryluk, John T McCrone, Ruben JG Hulswit, Lucas AM Franco, Mariana S Ramundo, Jaqueline G De Jesus, Pamela S Andrade, Thais M Coletti, Giulia M Ferreira, Camila AM Silva, Erika R Manuli, Rafael HM Pereira, Pedro S Peixoto, Moritz UG Kraemer, Nelson Gaburo Jr, Cecilia da C Camilo, Henrique Hoeltgebaum, William M Souza, Esmenia C Rocha, Leandro M De Souza, Mariana C De Pinho, Leonardo JT Araujo, Frederico SV Malta, Aline B De Lima, Joice do P Silva, Danielle AG Zauli, Alessandro C de S Ferreira, Ricardo P Schnekenberg, Daniel J Laydon, Patrick GT Walker, Hannah M Schlüter, Ana LP Dos Santos, Maria S Vidal, Valentina S Del Caro, Rosinaldo MF Filho, Helem M Dos Santos, Renato S Aguiar, José L Proença-Modena, Bruce Nelson, James A Hay, Mélodie Monod, Xenia Miscouridou, Helen Coupland, Raphael Sonabend, Michaela Vollmer, Axel Gandy, Carlos A Prete Jr, Vitor H Nascimento, Marc A Suchard, Thomas A Bowden, Sergei LK Pond, Chieh-Hsi Wu, Oliver Ratmann, Neil M Ferguson, Christopher Dye, Nick J Loman, Philippe Lemey, Andrew Rambaut, Nelson A Fraiji, Maria do PSS Carvalho, Oliver G Pybus, Seth Flaxman, Samir Bhatt, Ester C Sabino
发表日期
2021/5/21
期刊
Science
卷号
372
期号
6544
页码范围
815-821
出版商
American Association for the Advancement of Science
简介
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection …
学术搜索中的文章
NR Faria, TA Mellan, C Whittaker, IM Claro… - Science, 2021
NR Faria, TA Mellan, C Whittaker, IM Claro… - Brazil. medRxiv, 2021
NR Faria, TA Mellan, C Whittaker, IM Claro… - Nelson, JA Hay, M. Monod, X. Miscouridou, H …, 2021
NR Faria, TA Mellan, C Whittaker, IM Claro… - Published online March, 2021