作者
Christine Nardini, Jean-Francois Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani, Maria Giulia Bacalini
发表日期
2018/12/1
来源
Seminars in immunology
卷号
40
页码范围
49-60
出版商
Academic Press
简介
A growing amount of evidences indicates that inflammaging – the chronic, low grade inflammation state characteristic of the elderly – is the result of genetic as well as environmental or stochastic factors. Some of these, such as the accumulation of senescent cells that are persistent during aging or accompany its progression, seem to be sufficient to initiate the aging process and to fuel it. Others, like exposure to environmental compounds or infections, are temporary and resolve within a (relatively) short time. In both cases, however, a cellular memory of the event can be established by means of epigenetic modulation of the genome.
In this review we will specifically discuss the relationship between epigenetics and inflammaging. In particular, we will show how age-associated epigenetic modifications concerned with heterochromatin loss and gene-specific remodelling, can promote inflammaging. Furthermore, we will …
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