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Background: Platinum (Pt) is detectable for years after cisplatin treatment completion, but few studies have examined the extent of long-term exposure to Pt and associated co-morbidities. Methods: Eligible testicular cancer survivors (TCS, n = 633) given 300 or 400 ± 15 mg/m² cisplatin underwent lab tests and extensive audiometry, and completed questionnaires at follow-up (median 5 y, range 1-35). Since subject-level PK parameters cannot be estimated in cross-sectional designs, we regressed log(Pt) on dose and follow-up time in the entire cohort. Each subject’s PK trait was defined as the deviation from the average concentration-time curve (the residual). High values indicate Pt levels exceeding the expected value, i.e. slower elimination. The Pt reference interval (RI) used (central 95% of 147 non-Pt exposed patients) was 8-47 ng/L (JALM 2016; 1:2, 143). Linear regression at α = 0.05 was used for …