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J Oral Pathol Med (2010) 39: 48–55

Background:  Salivary glands tumors are relatively uncommon neoplasm with widely variable histopathologic and biologic characteristics. Alteration in some proto‐oncogenes and tumor suppressor genes may lead to the development and progression of these tumors.

Aims:  The purpose of this study was to analyze the immunohistochemical expression of P₅₃ and bcl‐2 in some salivary gland tumors in relation to tumor size, histologic grade, and extent of invasion.

Setting and design:  The sample consisted of 22 formalin‐fixed paraffin embedded blocks of benign and malignant salivary glands tumors.

Material and method:  P₅₃ and bcl‐2 immunoreactivity was semi‐quantitatively evaluated in at least 1000 cells examined under the microscope at 40× magnification and recorded as percentage of P₅₃ or bcl‐2 positive tumor cells over the total number of cells examined in the …