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Background: Oxidative stress is one of the mechanisms involved in neuronal damage induced by free radicals production in ischemic stroke due to ischemia-reperfusion. Antioxidants, on the other hand, may provide protection from neuronal damage caused by oxidative stress.

Objectives: The present study was designed to measure some oxidative stress marker and antioxidants in serum and saliva of ischemic stroke patients and patients with some stroke related diseases in an attempt to obtain the predictive value for ischemic stroke in stroke–prone individuals.

Methods: Serum and salivary Malondialdehyde (MDA) levels, glutathione (GSH), superoxide dismutase (SOD) and uric acid (UA) were estimated for 150 individuals, fifty of them were patients having recently diagnosed ischemic stroke, seventy five were sex and age matched risk-group patients (patients with hypertension, type2 diabetes and ischemic heart disease) and other 25 sex and age matched healthy control individuals.

Results: Serum GSH is considered as the most powerful predictor for ischemic stroke with critical value (< 1.52 µmol/L) followed by serum SOD with critical value (≥ 2.09 U/ml) and salivary SOD with critical range (1.54-1.80 U/ml) could be an alarming sign for stroke in patients with hypertension and patients with heart diseases. Conclusions: Serum and salivary MDA, SOD, UA and GSH can be used as potential marker for monitoring patients with hypertension, diabetes mellitus and patients with angina or myocardial infarction to give us an idea about the disease progression toward ischemic stroke.