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Health is our number one priority that is the foundation that we build our life. When traditional sensor networks have been migrated to Internet of things, humans and sensing devices are communicated and linked with internet. Quintillions bytes of data have been generated by humans every day. The ever-increasing ageing population has brought smart healthcare, as one of the crucial and promising visions of smart city and sustainability, relies heavily on the deployment of artificial intelligence (AI) and big data analytics (BDA) to improve the quality of life. The basic requirements for smart healthcare are first discussed. Five selected key applications are reviewed to demonstrate the effectiveness of AI and BDA models. For smart healthcare to be truly functional, emerging challenges in large-scale open health-care data, technology transfer, public acceptance in AI- and BDA-based applications, and policy …