作者
Sander M Daselaar, Dick J Veltman, Serge ARB Rombouts, Jeroen GW Raaijmakers, Cees Jonker
发表日期
2003/11/1
期刊
Neurobiology of aging
卷号
24
期号
7
页码范围
1005-1011
出版商
Elsevier
简介
Age-related impairments in episodic memory have been related to a deficiency in semantic processing, based on the finding that elderly adults typically benefit less than young adults from deep, semantic as opposed to shallow, nonsemantic processing of study items. In the present study, we tested the hypothesis that elderly adults are not able to perform certain cognitive operations under deep processing conditions. We further hypothesised that this inability does not involve regions commonly associated with lexical/semantic retrieval processes, but rather involves a dysfunction of the medial temporal lobe (MTL) memory system. To this end, we used functional MRI on rather extensive groups of young and elderly adults to compare brain activity patterns obtained during a deep (living/nonliving) and a shallow (uppercase/lowercase) classification task. Common activity in relation to semantic classification was …
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SM Daselaar, DJ Veltman, SARB Rombouts… - Neurobiology of aging, 2003