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Objectives:

To describe the characteristics of a large cohort of cancer patients receiving mechanical ventilation for> 24 hrs and to identify clinical features predictive of in-hospital death.

Design:

Prospective cohort study.

Setting:

Ten-bed oncologic medical-surgical intensive care unit.

Patients:

A total of 463 consecutive patients were included over a 45-month period.

Interventions:

None.

Measurements and Main Results:

Data were collected on the day of admission to the intensive care unit. The intensive care unit and hospital mortality rates were 50% and 64%, respectively. There were 359 (78%) patients with solid tumors and 104 (22%) with hematologic malignancies; 35 (8%) patients had leukopenia. Sepsis (63%), coma (15%), invasion or compression by tumor (11%), pulmonary embolism (7%), and cardiopulmonary arrest (6%) were the main reasons for mechanical ventilation. The independent unfavorable risk …