作者
Adriane M Soehner, Michele A Bertocci, Jessica C Levenson, Tina R Goldstein, Brian Rooks, John Merranko, Danella Hafeman, Rasim Diler, David Axelson, Benjamin I Goldstein, Mary Beth Hickey, Kelly Monk, Mary L Phillips, Boris Birmaher
发表日期
2019/6/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
58
期号
6
页码范围
608-617
出版商
Elsevier
简介
Objective
Sleep disturbance may be involved in symptom progression across multiple domains of psychopathology and could represent a target for treatment development in youth. Our objective was to identify sleep patterns that longitudinally change in conjunction with psychiatric symptom severity in at-risk youth.
Method
The study included 484 Pittsburgh Bipolar Offspring Study (BIOS) youth with at least 2 sleep assessments occurring between 10 and 18 years of age: 267 offspring of parents with bipolar I or II disorder and 217 community comparison offspring. Assessments occurred approximately every 2 years (mean number of assessments, 2.8 ± 0.8; mean follow-up duration, 3.8 ± 1.6 years). Offspring had a range of psychiatric diagnoses at baseline. Multivariate lasso regression was implemented to select offspring-reported sleep patterns associated with changes in five psychiatric symptom measures from …
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AM Soehner, MA Bertocci, JC Levenson, TR Goldstein… - Journal of the American Academy of Child & …, 2019