作者
The Tabula Sapiens Consortium*, Robert C Jones, Jim Karkanias, Mark A Krasnow, Angela Oliveira Pisco, Stephen R Quake, Julia Salzman, Nir Yosef, Bryan Bulthaup, Phillip Brown, William Harper, Marisa Hemenez, Ravikumar Ponnusamy, Ahmad Salehi, Bhavani A Sanagavarapu, Eileen Spallino, Ksenia A Aaron, Waldo Concepcion, James M Gardner, Burnett Kelly, Nikole Neidlinger, Zifa Wang, Sheela Crasta, Saroja Kolluru, Maurizio Morri, Serena Y Tan, Kyle J Travaglini, Chenling Xu, Marcela Alcántara-Hernández, Nicole Almanzar, Jane Antony, Benjamin Beyersdorf, Deviana Burhan, Kruti Calcuttawala, Matthew M Carter, Charles KF Chan, Charles A Chang, Stephen Chang, Alex Colville, Rebecca N Culver, Ivana Cvijović, Gaetano D’Amato, Camille Ezran, Francisco X Galdos, Astrid Gillich, William R Goodyer, Yan Hang, Alyssa Hayashi, Sahar Houshdaran, Xianxi Huang, Juan C Irwin, SoRi Jang, Julia Vallve Juanico, Aaron M Kershner, Soochi Kim, Bernhard Kiss, William Kong, Maya E Kumar, Angera H Kuo, Rebecca Leylek, Baoxiang Li, Gabriel B Loeb, Wan-Jin Lu, Sruthi Mantri, Maxim Markovic, Patrick L McAlpine, Antoine de Morree, Karim Mrouj, Shravani Mukherjee, Tyler Muser, Patrick Neuhöfer, Thi D Nguyen, Kimberly Perez, Ragini Phansalkar, Nazan Puluca, Zhen Qi, Poorvi Rao, Hayley Raquer-McKay, Nicholas Schaum, Bronwyn Scott, Bobak Seddighzadeh, Joe Segal, Sushmita Sen, Shaheen Sikandar, Sean P Spencer, Lea C Steffes, Varun R Subramaniam, Aditi Swarup, Michael Swift, Will Van Treuren, Emily Trimm, Stefan Veizades, Sivakamasundari Vijayakumar, Kim Chi Vo, Sevahn K Vorperian, Wanxin Wang, Hannah NW Weinstein, Juliane Winkler, Timothy TH Wu, Jamie Xie, Andrea R Yung, Yue Zhang, Angela M Detweiler, Honey Mekonen, Norma F Neff, Rene V Sit, Michelle Tan, Jia Yan, Gregory R Bean, Vivek Charu, Erna Forgó, Brock A Martin, Michael G Ozawa, Oscar Silva, Angus Toland, Venkata NP Vemuri, Shaked Afik, Kyle Awayan, Olga Borisovna Botvinnik, Ashley Byrne, Michelle Chen, Roozbeh Dehghannasiri, Adam Gayoso, Alejandro A Granados, Qiqing Li, Gita Mahmoudabadi, Aaron McGeever, Julia Eve Olivieri, Madeline Park, Neha Ravikumar, Geoff Stanley, Weilun Tan, Alexander J Tarashansky, Rohan Vanheusden, Peter Wang, Sheng Wang, Galen Xing, Les Dethlefsen, Po-Yi Ho, Shixuan Liu, Jonathan S Maltzman, Ross J Metzger, Koki Sasagawa, Rahul Sinha, Hanbing Song, Bruce Wang, Steven E Artandi, Philip A Beachy, Michael F Clarke, Linda C Giudice
发表日期
2022/5/13
期刊
Science
卷号
376
期号
6594
页码范围
eabl4896
出版商
American Association for the Advancement of Science
简介
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type–specific RNA splicing was discovered and analyzed across tissues within an individual.
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