作者
Soheil Yousefi, Tooba Abbassi-Daloii, Thirsa Kraaijenbrink, Martijn Vermaat, Hailiang Mei, Peter van ‘t Hof, Maarten van Iterson, Daria V Zhernakova, Annique Claringbould, Lude Franke, Leen M ‘t Hart, Roderick C Slieker, Amber van der Heijden, Peter de Knijff, Peter AC ’t Hoen
发表日期
2018/12
期刊
BMC genomics
卷号
19
页码范围
1-12
出版商
BioMed Central
简介
Background
SNP panels that uniquely identify an individual are useful for genetic and forensic research. Previously recommended SNP panels are based on DNA profiles and mostly contain intragenic SNPs. With the increasing interest in RNA expression profiles, we aimed for establishing a SNP panel for both DNA and RNA-based genotyping.
Results
To determine a small set of SNPs with maximally discriminative power, genotype calls were obtained from DNA and blood-derived RNA sequencing data belonging to healthy, geographically dispersed, Dutch individuals. SNPs were selected based on different criteria like genotype call rate, minor allele frequency, Hardy–Weinberg equilibrium and linkage disequilibrium. A panel of 50 SNPs was sufficient to identify an individual uniquely: the probability of identity was 6.9 × 10− 20 when assuming no …
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S Yousefi, T Abbassi-Daloii, T Kraaijenbrink… - BMC genomics, 2018