作者
Rehan Akbani, Kadir C Akdemir, B Arman Aksoy, Monique Albert, Adrian Ally, Samirkumar B Amin, Harindra Arachchi, Arshi Arora, J Todd Auman, Brenda Ayala, Julien Baboud, Miruna Balasundaram, Saianand Balu, Nandita Barnabas, John Bartlett, Pam Bartlett, Boris C Bastian, Stephen B Baylin, Madhusmita Behera, Dmitry Belyaev, Christopher Benz, Brady Bernard, Rameen Beroukhim, Natalie Bir, Aaron D Black, Tom Bodenheimer, Lori Boice, Genevieve M Boland, Riccardo Bono, Moiz S Bootwalla, Marcus Bosenberg, Jay Bowen, Reanne Bowlby, Christopher A Bristow, Laura Brockway-Lunardi, Denise Brooks, Jakub Brzezinski, Wiam Bshara, Elizabeth Buda, William R Burns, Yaron SN Butterfield, Michael Button, Tiffany Calderone, Giancarlo Antonini Cappellini, Candace Carter, Scott L Carter, Lynn Cherney, Andrew D Cherniack, Aaron Chevalier, Lynda Chin, Juok Cho, Raymond J Cho, Yoon-La Choi, Andy Chu, Sudha Chudamani, Kristian Cibulskis, Giovanni Ciriello, Amanda Clarke, Stephen Coons, Leslie Cope, Daniel Crain, Erin Curley, Ludmila Danilova, Stefania D’Atri, Tanja Davidsen, Michael A Davies, Keith A Delman, John A Demchok, Qixia A Deng, Yonathan Lissanu Deribe, Noreen Dhalla, Rajiv Dhir, Daniel DiCara, Michael Dinikin, Michael Dubina, J Stephen Ebrom, Sophie Egea, Greg Eley, Jay Engel, Jennifer M Eschbacher, Konstantin V Fedosenko, Ina Felau, Timothy Fennell, Martin L Ferguson, Sheila Fisher, Keith T Flaherty, Scott Frazer, Jessica Frick, Victoria Fulidou, Stacey B Gabriel, Jianjiong Gao, Johanna Gardner, Levi A Garraway, Julie M Gastier-Foster, Carmelo Gaudioso, Nils Gehlenborg, Giannicola Genovese, Mark Gerken, Jeffrey E Gershenwald, Gad Getz, Carmen Gomez-Fernandez, Thomas Gribbin, Jonna Grimsby, Benjamin Gross, Ranabir Guin, Tony Gutschner, Angela Hadjipanayis, Ruth Halaban, Benjamin Hanf, David Haussler, Lauren E Haydu, D Neil Hayes, Nicholas K Hayward, David I Heiman, Lynn Herbert, James G Herman, Peter Hersey, Katherine A Hoadley, Eran Hodis, Robert A Holt, Dave SB Hoon, Susan Hoppough, Alan P Hoyle, Franklin W Huang, Mei Huang, Sharon Huang, Carolyn M Hutter, Matthew Ibbs, Lisa Iype, Anders Jacobsen, Valerie Jakrot, Alyssa Janning, William R Jeck, Stuart R Jefferys, Mark A Jensen, Corbin D Jones, Steven JM Jones, Zhenlin Ju, Hojabr Kakavand, Hyojin Kang, Richard F Kefford, Fadlo R Khuri, Jaegil Kim, John M Kirkwood, Joachim Klode, Anil Korkut, Konstanty Korski, Michael Krauthammer, Raju Kucherlapati, Lawrence N Kwong
发表日期
2015/6/18
期刊
Cell
卷号
161
期号
7
页码范围
1681-1696
出版商
Cell Press
简介
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a Tácell marker, were associated with improved patient survival. This clinicopathological and multi …
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