作者
Marco A Marra, Steven JM Jones, Caroline R Astell, Robert A Holt, Angela Brooks-Wilson, Yaron SN Butterfield, Jaswinder Khattra, Jennifer K Asano, Sarah A Barber, Susanna Y Chan, Alison Cloutier, Shaun M Coughlin, Doug Freeman, Noreen Girn, Obi L Griffith, Stephen R Leach, Michael Mayo, Helen McDonald, Stephen B Montgomery, Pawan K Pandoh, Anca S Petrescu, A Gordon Robertson, Jacqueline E Schein, Asim Siddiqui, Duane E Smailus, Jeff M Stott, George S Yang, Francis Plummer, Anton Andonov, Harvey Artsob, Nathalie Bastien, Kathy Bernard, Timothy F Booth, Donnie Bowness, Martin Czub, Michael Drebot, Lisa Fernando, Ramon Flick, Michael Garbutt, Michael Gray, Allen Grolla, Steven Jones, Heinz Feldmann, Adrienne Meyers, Amin Kabani, Yan Li, Susan Normand, Ute Stroher, Graham A Tipples, Shaun Tyler, Robert Vogrig, Diane Ward, Brynn Watson, Robert C Brunham, Mel Krajden, Martin Petric, Danuta M Skowronski, Chris Upton, Rachel L Roper
发表日期
2003/5/30
期刊
Science
卷号
300
期号
5624
页码范围
1399-1404
出版商
American Association for the Advancement of Science
简介
We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.
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