作者
Samer Al Hadidi, Aniko Szabo, Jean Esselmann, Lindsay Hammons, Munawwar Hussain, Yetunde Ogunsesan, Nishanth Thalambedu, Fatima Khan, Jaskirat Sethi, Abhishek Janardan, Sabarinath Venniyil Radhakrishnan, Sharmilan Thanendrarajan, Carolina Schinke, Binod Dhakal, Siegfried Janz, Saurabh Chhabra, Anita D’Souza, Maurizio Zangari, Frits van Rhee, Meera Mohan
发表日期
2023/4
期刊
Bone Marrow Transplantation
卷号
58
期号
4
页码范围
443-445
出版商
Nature Publishing Group UK
简介
The first chimeric antigen receptor T cell (CAR-T) therapy in multiple myeloma (MM), idecabtagene vicleucel, directed against B-cell maturation antigen (BCMA), was approved in March 2021 for use in relapsed/refractory (RR) disease. In clinical trials, high response rates were reported with CAR-T therapy in heavily pretreated patients with MM [1-3]. In limited real-world experience since approval, the use of CAR-T therapy in patients with RRMM has also resulted in high response rates; however, the outcome of patients who were eligible for CAR-T therapy but did not receive it has not been studied [4]. We investigated the realworld experience of outcomes of patients with RRMM placed on commercial CAR-T therapy wait-list since its initial approval in March 2021. Methods including patients and disease variables along with statistical analysis were provided in supplementary. A total of 81 patients were listed for …
引用总数