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Hematopoietic cell transplantation (HCT) and cellular therapy (CT) recipients have poor outcomes after developing COVID-19 (Spanjaart et al., 2021, Meir et al., 2021). HCT and/or CT recipients also have blunted responses to SARS-CoV-2 vaccines (Dhakal et al., 2021). Several groups, including ours, have indicated a response rate of 50%–80% among HCT recipients and 20%–30% among chimeric antigen receptor (CAR) T cell recipients (Dhakal et al., 2021, Meir et al., 2021, Abid and Abid, 2021). The general population has demonstrated sustained and durable immune responses to an additional mRNA vaccine dose (‘‘booster’’) to counteract the waning immunity to the primary vaccination series (Nemet, Kliker, Lustig, Zuckerman, Erster, Cohen, Kreiss, Alroy-Preis, Regev-Yochay, Mendelson, Mandelboim, 2022). It remains unknown whether HCT and/or CT recipients respond to the additional primary or …